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CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3.
Malik B, Hemenway CS. Malik B, et al. FEBS Lett. 2013 Sep 17;587(18):3038-44. doi: 10.1016/j.febslet.2013.07.034. Epub 2013 Jul 25. FEBS Lett. 2013. PMID: 23891621 Free PMC article.
Specifically, we show that AF9 is part of a protein multimer containing members of Polycomb group (PcG) PRC1 complex, CBX8, RING1B, and BMI1. Interaction with CBX8 precludes AF9-DOT1L binding. Knockdown of CBX8 with short-hairpin RNA (shRNA) leads to d …
Specifically, we show that AF9 is part of a protein multimer containing members of Polycomb group (PcG) PRC1 complex, CBX8, RING1B, a …
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.
Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH. Dietrich N, et al. EMBO J. 2007 Mar 21;26(6):1637-48. doi: 10.1038/sj.emboj.7601632. Epub 2007 Mar 1. EMBO J. 2007. PMID: 17332741 Free PMC article.
Furthermore, we demonstrate that CBX8 is limiting for the regulation of INK4A-ARF, and that ectopic expression of CBX8 leads to repression of the Ink4a-Arf locus and bypass of senescence, leading to cellular immortalization. Gene expression and location analysis dem …
Furthermore, we demonstrate that CBX8 is limiting for the regulation of INK4A-ARF, and that ectopic expression of CBX8 leads t …
B-cell-specific Moloney murine leukemia virus integration site 1 knockdown impairs adriamycin resistance of gastric cancer cells.
Ma N, Zhao S, Yang W, Wang Y. Ma N, et al. Arab J Gastroenterol. 2023 Aug;24(3):168-174. doi: 10.1016/j.ajg.2023.02.004. Epub 2023 Mar 4. Arab J Gastroenterol. 2023. PMID: 36878814
Knocking down BMI-1 significantly decreased epithelial-mesenchymal transition progression, expression levels of drug-resistant proteins, and the number of SP cells in ADR-treated GC cells. Bioinformatics analysis showed that EZH2, CBX8, CBX4, and SUZ12 were positively corr …
Knocking down BMI-1 significantly decreased epithelial-mesenchymal transition progression, expression levels of drug-resistant proteins, and …
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J, Rodriguez-Niedenführ M, Gil J, Peters G. Maertens GN, et al. PLoS One. 2009 Jul 28;4(7):e6380. doi: 10.1371/journal.pone.0006380. PLoS One. 2009. PMID: 19636380 Free PMC article.
Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene. Using tandem affinity purification, we find that CBX7 and CBX8, two Polyco …
Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by mo …
PRC1 components exhibit different binding kinetics in Polycomb bodies.
Vandenbunder B, Fourré N, Leray A, Mueller F, Völkel P, Angrand PO, Héliot L. Vandenbunder B, et al. Biol Cell. 2014 Apr;106(4):111-25. doi: 10.1111/boc.201300077. Epub 2014 Mar 6. Biol Cell. 2014. PMID: 24460908
RESULTS: Fluorescently tagged PcG proteins CBXs and their partners BMI1 and RING1 form foci of different sizes and intensities in human U2OS cells. ...CBX4-green fluorescent protein (GFP) foci were more stable than CBX8-GFP foci; yet the presence of CBX4 or CBX8 …
RESULTS: Fluorescently tagged PcG proteins CBXs and their partners BMI1 and RING1 form foci of different sizes and intensities in hum …
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Vandamme J, Völkel P, Rosnoblet C, Le Faou P, Angrand PO. Vandamme J, et al. Mol Cell Proteomics. 2011 Apr;10(4):M110.002642. doi: 10.1074/mcp.M110.002642. Epub 2011 Jan 31. Mol Cell Proteomics. 2011. PMID: 21282530 Free PMC article.
Each of these proteins has multiple orthologs in vertebrates classified respectively as the CBX, RING1/RNF2, PHC, and BMI1/PCGF families. Mammalian genomes encode five CBX family members (CBX2, CBX4, CBX6, CBX7, and CBX8) that are believed to have distinct biologica …
Each of these proteins has multiple orthologs in vertebrates classified respectively as the CBX, RING1/RNF2, PHC, and BMI1/PCGF famil …
Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma.
Gao SB, Sun SL, Zheng QL, Zhang L, Zhu Y, Jin GH, Xue LX. Gao SB, et al. Am J Cancer Res. 2015 Sep 15;5(10):2969-79. eCollection 2015. Am J Cancer Res. 2015. PMID: 26693053 Free PMC article.
Furthermore, Immunohistochemical staining revealed that the expression levels of CBX8 (in 53/123 samples) and BMI1 (in 60/130 samples) were markedly increased in human HCC specimens. ...
Furthermore, Immunohistochemical staining revealed that the expression levels of CBX8 (in 53/123 samples) and BMI1 (in 60/130 …
Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation.
Li J, Li SH, Dong J, Alibhai FJ, Zhang C, Shao ZB, Song HF, He S, Yin WJ, Wu J, Weisel RD, Liu SM, Li RK. Li J, et al. Aging Cell. 2019 Dec;18(6):e13026. doi: 10.1111/acel.13026. Epub 2019 Aug 5. Aging Cell. 2019. PMID: 31385396 Free PMC article.
Four months later, expression of rejuvenation-related genes (Bmi1, Cbx8, PNUTS, Sirt1, Sirt2, Sirt6) and proteins (CDK2, CDK4) was increased along with telomerase activity and telomerase-related protein (DNA-PKcs, TRF-2) expression, whereas expression of senescence- …
Four months later, expression of rejuvenation-related genes (Bmi1, Cbx8, PNUTS, Sirt1, Sirt2, Sirt6) and proteins (CDK2, CDK4) …
Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium.
Goldstein BJ, Choi R, Goss GM. Goldstein BJ, et al. Laryngoscope Investig Otolaryngol. 2018 Sep 17;3(5):337-344. doi: 10.1002/lio2.180. eCollection 2018 Oct. Laryngoscope Investig Otolaryngol. 2018. PMID: 30410986 Free PMC article.
We identified PRC1 components including MEL18 (PCGF2) in immature neurons, and confirm BMI1 (PCGF4) expression in mature neurons. Moreover, we identified CBX8 as a neuron-specific PRC1 subunit. ...
We identified PRC1 components including MEL18 (PCGF2) in immature neurons, and confirm BMI1 (PCGF4) expression in mature neurons. Mor …